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Multiple stimuli, such as excessive noise, ototoxic drugs, hereditary defects, and aging process, can cause SGNs damage

One drug in trials would require only monthly injections, and many candidate drugs are oral

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Additionally, in murine models exposed to dexamethasone, it was observed that the excretion of N-methylhistidinea marker indicative of muscle protein breakdownappeared reduced to a greater extent by IGF-1 LR3, potentially threefold more than by IGF-I

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