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Incorporating multi-objective optimization strategies to simultaneously address key properties such as drug activity, synthetic feasibility, and other critical factors will further enable the generation of linkers that meet specific design requirements, advancing the development of next-generation ADCs

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Improved intestinal absorption results from enhanced permeation through tight junction modulation, lymphatic targeting via lipid-based systems, receptor-mediated endocytosis, and size-dependent paracellular transport

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Always verify your calculations and consult appropriate guidelines for your specific research application