Membranes were stripped in Restore Plus Western Blot stripping buffer (46430, Thermo Fisher Scientific) for 1 h, washed with TBST (three times, 15 min each), blocked with 5% BSA and reprobed with primary antibody to eIF4E (Cell Signaling Technology) overnight at 4 C
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Efficacy Comparison Table The PIONEER 10 trial directly compared oral semaglutide with dulaglutide in Japanese adults with type 2 diabetes over 52 weeks
To assess whether patients with more advanced disease would benefit from long-acting treatments, patients were matched to the baseline characteristics of basal insulin initiators using inverse probability of treatment weighting (IPTW)
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These trials were not intended to assess CV benefit in the general population with T2DM (most patients being in primary prevention) and are best interpreted as evidence for CV safety of these new antihyperglycemic medications in patients with T2DM and very high risk