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HIF1A and HIF2A knockdown in hypoxic HK2 cells In a previous study, 10 immortalized human proximal tubular epithelial (HK2) cells with and without stable HIF1A and/or HIF2A (EPAS1) suppression were subjected to normoxic (20% O 2 ) or hypoxic (1% O 2 ) conditions for 24 h

It was suggested that inactivated or down-regulated GSTP1 and GSTA1 genes could increase genomic damage when individuals were exposed to carcinogens

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Dermatologic Surgery 28(3):p 231-236, March 2002.