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This is consistent with the fact that this class of drugs produces significant appetite suppression in response to central and peripheral GLP-1 R activation and has been actively used in the treatment of T2DM, obesity, and overweight ( Our study identified a potential risk of dehydration with dulaglutide, liraglutide, semaglutide, and tirzepatide, semaglutide emerged as having the highest risk of various fluid reductions (Supplementary Table S2)

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Genetic association study of NOD2 and IL23R amino acid substitution polymorphisms in Saudi inflammatory bowel disease patients