215 In patients with mild AD/cognitive impairment (MCI), a combination of L-arginine, HMG-CoA inhibitor simvastatin, and tetrahydrobiopterin to enhance the endothelial nitric oxide synthase (eNOS) pathway modestly increases cerebral blood flow and improves cognition
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FSP1 is recently identified as a breakthrough owing to its unique ability to suppress ferroptosis by reducing ubiquinone to ubiquinol 2,3 , or vitamin K to reduced hydroquinone (VKH2) 17
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Sappanone A similarly combats inflammation and ECM degradation in OA by attenuating chondrocyte ferroptosis through the SIRT1/Nrf2 pathway (165)