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The severity of the symptoms varies widely, from mild to very serious impairment

J Inherit.Metab Dis 2009;32(4):488-497

It represents a precautionary approach given limited long-term data rather than a response to documented concerns

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This pattern aligns with B12 pharmacokinetics: serum levels peak 8-12 hours post-injection, tissue saturation occurs over 48-72 hours (Andrs et al., Journal of Blood Medicine , 2018)