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Obes Rev 9(5):489500 Dalle Grave R, Calugi S, El Ghoch M (2013) Lifestyle modification in the management of obesity: achievements and challenges

Triple Receptor Action Retatrutide is the first medication designed to simultaneously activate GLP-1, GIP, and glucagon receptors

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The smaller final step from 8mg to 12mg (a 50% increase rather than a 100% doubling) reflects the finding that GI tolerability improves at higher doses once the body has already adapted to substantial receptor activation

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