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When tested as a once-daily injection in single and multiple doses varying up to 0.18 mg in healthy normal to overweight volunteers, gastrointestinal adverse events (nausea, diarrhoea, constipation, vomiting) were encountered, but the drug was described as well tolerated

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Mechanistically, BPC-157 appears to function through nitric oxide-mediated vasodilation, angiogenic factor regulation, and recruitment of fibroblasts and endothelial progenitor cells 1-3