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Mohammadi et al., 2024)
Common lab protocols involve reconstitution in bacteriostatic water and subcutaneous injection in animal models using calibrated syringes to achieve precise dosing
We previously reported spontaneous mouse models of NTG, and these mice lacked the glutamate transporter gene excitatory amino-acid carrier 1 (EAAC1
Despite the aforementioned potentially toxic profile and limitations of TDM, Tac remains the most relevant immunosuppressant in therapy of patients after solid organ transplantation, which has led to a broad variety of studies addressing Tac metabolism and optimization of dosing
IRE1 is a type I transmembrane ER resident protein that contains two enzymatic activities, serine/threonine kinase and endoribonuclease (RNase) activities
doi: 10.1084/jem.20170771 110 BaileyAPKosterGGuillermierCHirstEMMacRaeJILecheneCPet al
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