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263 Additionally, DJ-1 may function as a scaffold protein facilitating the interaction between signal-transducers and activators of transcription (STAT1) and its phosphatase, Src-homology 2-domain containing protein tyrosine phosphatase-1 (SHP-1) that negatively regulates inflammatory responses of microglia

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61 Changes in patients HRQoL were not as great from baseline till end of trial in Study 2 which included diabetes patients, which resulted in lower construct validity compared to Study 1 which enrolled patients with the goal of weight loss

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