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Main Genetic Factors Predisposing You to Histamine Intolerance Certain genetic variations can predispose you to histamine intolerance, including those in the following genes: MTHFR : MTHFR helps regulate methylation which is needed to reduce intracellular histamine by the HNMT route

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Mehta et al., 2020) that can cause acute respiratory distress syndrome, lung injury, respiratory insufficiency, endothelial cell dysfunction, thrombosis, cardiovascular disease and end-organ damage (Klok et al., 2020

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