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Common side effects include headache, flushing, indigestion, and nasal congestion

Gene signatures derived from transcriptomic-causal networks stratified colorectal cancer patients for effective targeted therapy

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14 The cytokines like IL-1 lead to activate PI3K/AKT signaling when it binds to the cell surface receptor

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The efficacy of setmelanotide may not be sufficient for POMC-MC4R deficient patients because body weight reduction ratio of semaglutide and tirzepatide were 12.4 and 17.8%, respectively in clinical study as compared with that of setmelanotide, 5.2% [[18, 19, 23]]