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Glutathione depletion as a mechanism of Parkinson's disease: midlife depletion in animals induces symptoms and disability www.sciencedaily.com Depleting glutathione may cause Parkinsons: Mice induced to have glutathione depletion as young adults did not develop Parkinsonian-like nerve damage and symptoms, while those who suffered from the depletion in late middle age did develop a loss of dopaminergic neurons specifically related to PD

Increased production of ROS and RNS usually result in production of more potent peroxynitrite (ONOO ), which interacts with cellular macromolecules such as DNA, proteins, and lipids to produce oxidized DNA, proteins, and lipid peroxides, respectively [46]

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