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Originally developed to treat type 2 diabetes, clinical studies show that semaglutide can help patients lose 1522% of body weight when combined with lifestyle changes

This contraindication reflects the theoretical concern that GLP-1 receptor stimulation could promote recurrence or progression of residual C-cell disease, even though human C-cells express minimal GLP-1 receptors

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However, in a subanalysis of patients with advanced adenoma at baseline (n=161), selenium supplementation reduced adenoma recurrence by 18% (88)

Patients should also continue with healthy eating habits and regular exercise while taking GLP-1

Because of the increased vascular permeability and breakdown of the blood-retinal barrier, fluid and lipids leak into the retina and cause it to swell