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Our most advanced candidate, danuglipron, has shown good efficacy in a twice-daily formulation, and we believe a once-daily formulation could be highly competitive in the oral GLP-1 space, said Mikael Dolsten, MD., PhD., Chief Scientific Officer & President, Pfizer Research and Development

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Daily administration would produce accumulating plasma levels far beyond the studied range, dramatically increasing side effects without proportional benefit

Biosocial variation in treatment response to GLP-1s: implications for clinical care and health policy

If more than 4 days have passed, skip the missed dose and take the next scheduled dose at the normal time