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The calcium-sensing receptor (CaSR) on somatostatin-producing D-cells in the stomach and hypothalamus responds to acute rises in ionized calcium by increasing somatostatin secretion [13]

Patient's Stories See What's Possible It might not be about willpower

individuals treated with orlistat lost more weight after 4 years, and the results were similar in those with or without prediabetes

Even people who achieve the treatment goals with the new obesity pharmacotherapies might decide to undergo bariatric surgery to support long-term weight maintenance because either they experience weight regain on the medication or they do not have long-term access to obesity pharmacotherapy, or they prefer not to take obesity pharmacotherapy lifelong