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GLP-1RAs, widely used for type 2 diabetes mellitus and obesity, activate pathways that overlap with insulin signaling
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Cell Stem Cell 29, 933947.e6
In a cohort of 76 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a condition that shares several clinical and mechanistic features with FM (e.g., chronic pain and fatigue, oxidative and nitrosative stress), nutraceuticals with anti-inflammatory and antioxidant properties (e.g., L-carnitine, coenzyme Q10, taurine, lipoic acid, curcumin, quercetin, N-acetylcysteine and zinc) were associated with reductions in IgM-mediated autoimmune responses against oxidative stress-related epitopes (OSEs) and nitrosative adducts (NO-adducts), together with improvements in symptoms [64]
Some researchers appreciate getting these secondary benefits alongside their tirzepatide protocol, though the amounts included in compounded formulations are typically modest
Always consult with a healthcare provider before starting any supplementation regimen
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