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Radford JA, Shalet SM, Lieberman BA

The peptide's development focused on enhancing hydrophobicity, decreasing hydrogen bonding potential, and increasing metabolic stability, resulting in a compound with an exceptionally long plasma half-life of approximately 335 minutes

Smart (2007) and Smart (2014) extended these observations to post-MI cardiac regeneration

Both MTX and 7-hydroxy MTX are excreted by the kidneys, and a small part is also excreted in the bile (Reference Saka and Aouacheri2)

Hou YQ, Li XL, Dai ZL, Wu ZL, Bazer FW, Wu G

These fatty acids help to stabilize the phospholipid molecule, and the phosphate group gives it polarity, meaning that it can interact with water