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Each specimen was scored using a scale ranging from 03 (0: none, 1: mild, 2: moderate, and 3: severe) for each criterion and a final histology score was determined [55]

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Our kinetic data indeed support an enzymatic reduction of roGFP2(S 2 ) that requires a ternary complex between the glutaredoxin, GSH, and the non-glutathione disulfide substrate (Fig