GLP-1 drugs like Ozempic slow gastric emptying by design - in most patients this is mild and temporary, but in some it becomes severe and irreversible
Dose escalation can also shape tolerability across GLP-1 medicines
The substrates 5-HT and MDMA also induced SERT internalization, while cocaine elevated SERT cell surface expression
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GDH activity is also increased in tumor cells
Always check for any changes in color or clarity, as this can indicate degradation