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Conflict of interest AMC has received honoraria as a speaker from Bayer, Bohringer-Ingelheim, Lilly, Novo-Nordisk, Esteve and Merck-Sharp-Dhme, and has participated in advisory boards from Bohringer-Ingelheim, Lilly and Merck-Sharp-Dhme

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This observation is in line with the epidemiological studies, linking pathological impulsivity with weight gain and dysmetabolism ( Multiple psychiatric studies over the past decades established that acetylcholine (ACh) and monoamines (MAs) including norepinephrine, dopamine, histamine, and serotonin are involved in a wide range of psychiatric disorders, including those marked by pathological impulsivity ( The development of PTDs with fewer metabolic adverse effects currently represents a major unmet need in psychiatry

Administration of GLP-1 Most GLP-1 therapies are injected subcutaneously, under the skin

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