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Structural and biophysical studies using NMR and small-angle X-ray scattering have demonstrated that GSH directly participates in Fe-S cluster assembly, including formation of mitochondrial Fe-S biosynthetic complexes essential for respiratory chain function 204,205

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Consequently, large, long-term, and specifically designed randomized controlled trials (RCTs) are necessary to accurately evaluate GLP-1 RAs impact on hypertension and determine their potential benefits and limitations [86]