Contact your GP, prescribing clinician or NHS 111 if you experience: Diarrhoea that persists for more than 7 days Signs of dehydration including excessive thirst, dark urine, dizziness, very little or no urination, confusion, or inability to keep fluids down Blood in stools or black, tarry stools suggesting gastrointestinal bleeding Severe abdominal pain , particularly if constant, worsening, or accompanied by fever Unintentional weight loss beyond expected therapeutic effects Symptoms of pancreatitis such as persistent severe upper abdominal pain radiating to the back, nausea, and vomitingthis requires urgent medical assessment [1] Patients with pre-existing gastrointestinal conditions including inflammatory bowel disease, irritable bowel syndrome, or previous bowel surgery should maintain closer monitoring, as Mounjaro may exacerbate underlying conditions
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The Cox proportional hazards regression model showed a higher NAION risk in the semaglutide cohort vs the non-semaglutide cohort (HR, 7.64
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