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The complex I and complex III of ETC are able to produce the superoxide anion radical (O 2 ) and release it to both the matrix and the intermembrane space

J Clin Endocrinol Metab 105:19371946

Furthermore, Doxorubicin and Cyclophosphamide reduced synaptic plasticity via hindering expression of brain-derived neurotrophic factor, phosphorylated cyclase response element binding protein, synaptophysin, and postsynaptic density protein 95 whereas protein expression of such synaptic plasticity biomarkers was enhanced by L-carnitine treatment

In the experimental period, the low-dose groups (A2 and C) were administered 50 mg/kg l-carnitine via intraperitoneal injection once a day, and the high-dose groups (A3 and D) were given 100 mg/kg

Injectable approaches remain practitioner-reported and extrapolated from preclinical research

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