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This systematic review of studies published over the last decade aimed to comprehensively evaluate the safety and efficacy of CA for the management of AWE

Common paediatric causes include: Biliary atresia and other congenital bile duct problems Inherited metabolic conditions such as Wilsons disease, alpha-1 antitrypsin deficiency, and glycogen storage disorders Autoimmune hepatitis Chronic viral hepatitis B or C , often acquired around birth Paediatric MASLD , increasingly common with rising childhood obesity Care is led by paediatric hepatologists where available

Causes dry mouth and sometimes blurred vision but extremely effective for some patients

Despite an initial severe presentation, she has had normal intellectual development and few complications of her disorder with a treatment regimen that includes polycitra (citric acid, potassium citrate and sodium citrate), vitamin C, vitamin E and selenium

Wolf et al., 2021)