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In its clinical trials, patients lost an average of 5% to 10% of their body weight

Protocol three: optimize hydration and electrolytes Dehydration impairs fat oxidation, reduces exercise performance, increases perceived fatigue, and promotes water retention paradoxically, because a dehydrated body holds onto fluid more aggressively

doi:10.1152/ajpendo.2000.279.3.E501 (source) Banfi G, Marinelli M, Roi GS, et al