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In many experimental animal models, MTX has been found to increase serum urea and creatinine levels (Reference Moodi, Hosseini and Abedini16,Reference Tousson, Zaki and Abu-Shaeir50,Reference Jafaripour, Naserzadeh and Alizamani51) , but there are also studies showing that MTX reduces serum urea concentration (Reference Budancamanak, Kanter and Demirel52Reference Severin, Campagno and Brandoni54)

5 Exercise regulates ferroptosis Ferroptosis is a critical pathophysiological mechanism closely associated with the pathogenesis and progression of multiple diseases

Once absorbed, the body converts it into usable forms of B12 that support DNA synthesis, red blood cell production, and neurological function

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