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Guidelines suggest the additional use of DPP-4 inhibitors after metformin failure in patients that do not require antidiabetic therapy with proven cardiovascular benefit

A longitudinal study published in Diabetologia (2019) followed over 900 non-diabetic individuals and found that higher circulating palmitoleic acid levels were independently associated with better insulin sensitivity, improved beta-cell function, and better glucose toleranceeven after adjusting for age, sex, and body fat

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The plasmids generated in the work have been deposited to Addgene