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The percentage of spontaneous alteration was calculated as follows: 100% number of triads containing entries into all 3 arms/maximum possible alternations (the total number of arms entered - 2)

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But high pH cannot be used with silica-based phases

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Su efecto pigmentario es acumulativo: la melanognesis inducida se manifiesta de forma progresiva a lo largo de das a semanas de administracin repetida, y el oscurecimiento persiste mientras se mantiene la estimulacin del MC1R, revirtindose gradualmente al suspenderla conforme se renuevan los melanocitos