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These hallmarks encompass genomic instability, the shortening of telomeres, deregulated nutrient sensing, mitochondrial dysfunction, changes in epigenetic regulation, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication (Shay and Wright, 2019

Although the exact etiology of RA is unclear, it is certain that genetic and environmental factors have influences on RA occurrence

Therefore, it is not surprising that efforts trying to integrate CYP3A5 status into Tac dosing considerations were often disappointing regarding safety or outcome (5759)

The disruption that occurs in healthy aging may become more detrimental when exposed to a second hit, such as inflammation

Notably, the research paradigm of multifunctional enzymes has increasingly extended into the field of biomimetic materials

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