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This bypass of the traditional Hayflick limit suggests a profound impact on cellular replicative lifespan

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Common adverse reactions included nausea, diarrhea, and vomiting

Mechanism 1: Upregulation of Growth Hormone Receptors (GHRs) This is the most critical mechanism for chronic tendinopathy

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

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