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JNK phosphorylates c-Jun, which translocates into the nucleus, and binds to the TRE element

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The prodrug was stable in normal tissues but can be easily hydrolyzed into DON in P493B lymphoma cells, inhibiting tumor cell proliferation in a dose-dependent manner (Tenora et al., 2019)

Figure 2 2.2.3 Clinical implications and therapeutic considerations The clinical relevance of toll-like receptor 4 (TLR4) signaling is evident in human disease states, particularly in alcohol-related liver pathology