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Wang S, Xiang D, Tian F, Ni M

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For example, non-functional SNVs of CYP2C9*2 and CYP2C9*3 are associated with decreased VPA metabolism, so patients who are homozygous for CYP2C9*2 or CYP2C9*3 or who are heterozygous (CYP2C9*2/*3) have a PM phenotype and show decreased P-oxidation of VPA in liver microsomes [69]

doi: 10.3201/eid2502.181011 42 ScottJTSesayFRMassaquoiTAIdrissBRSahrFSempleMG

Under basal conditions, adenosine mainly acts on inhibitory A 1 receptors (A 1 R) and excitatory A 2A Rs to integrate dopamine and glutamate signaling, which controls the synaptic plasticity associated with learning, memory, and cognition [5]