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Finally, Drosophila do not have an adaptive immune system, which complicates both the study of tissue restitution after injury and the underlying crosstalk with intestinal microbes
While NSAIDs impair recovery through gut injury, nutrient depletion, cardiovascular strain, and delayed tissue repair, opioids alter pain through a fundamentally different mechanismsuppressing central pain perception without addressing inflammatory or structural drivers
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Thereby, BPC 157 effects on counteraction of ketamine-cognition dysfunction, social withdrawal, and anhedonia, and exerted additional anxiolytic effect, in addition to well-suited models (i.e., cognitive dysfunction (novel object recognition test)) [207,208,209], social withdrawal [210,211], anhedonia (sucrose test) [212,213], anxiogenic effect (open field test) [214,215], can have a particular background
