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Appetite response and weight changes are reviewed over time to ensure that treatment remains effective and sustainable

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12 According to prescribing information, metformin is contraindicated in men with a serum creatinine level of 1.5 mg per dL (133 mol per L) or greater and in women with a serum creatinine level of 1.4 mg per dL (124 mol per L) or greater

Once activated, SMO initiates an intracellular cascade culminating in the activation of GLI transcription factors (GLI1, GLI2, GLI3)

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Colesevelam, which requires a much lower quantity of drug because of its high affinity and binding capacity for bile salts, has less of an effect on the absorption of other drugs than other bile acid sequestrants but can still adversely affect the absorption of certain drugs (Table 30) (424)