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Since their approval by the United States Food and Drug Administration (FDA), GLP1RA prescriptions have quadrupled over the past 4 years, with 4.7 million individuals in the United States using these agents in 2022 (Figure S1)

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The comparison between semaglutide, tirzepatide, and retatrutide reveals the rapidly advancing science of GLP-1 based treatments

While both peptides are widely marketed online, the quality of evidence varies, and much of the research is still preclinical, animal-based, or early-stage

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Inclusion criteria encompassed human and animal studies examining the impact of GLP-1 RAs on mental health