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Although antibiotics can speed up the reduction of symptoms, they can also cause side effects, such as digestive problems or weakened immunity

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Also, there is growing concern regarding concussion-induced cortical damage seen in children and young adults who participate in American football (chronic traumatic encephalopathy), boxing, martial arts, and soccer (due to headers) [35,36]

These cells remain metabolically active, adopt a distinct phenotype (including chromatin changes), and critically secrete a variety of pro-inflammatory cytokines, proteases, growth-factors and extracellular-matrix modifying signals

Front Immunol (2020) 11:13