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It has been shown to counter the effects of NSAIDs like ibuprofen or Advil in the stomach

doi:10.1001/jama.281.24.2289

Comparison with pregabalin: A study in Canada among 44 people with nerve pain due to various conditions compared alpha-lipoic acid directly to pregabalin (Lyrica), a first-line prescription drug for neuropathic pain

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Accordingly, hyperfiltration decreases according to tubular glomerular feedback due to increased Na in the distal tubule