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This oxidative damage severely impairs the mitochondria's ability to produce adenosine triphosphate (ATP), the currency of cellular energy

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Abbreviations RIP: Radiation-induced proctitis ROS: Reactive oxygen species EGCG: Epigallocatechin gallate MPO: Myeloperoxidase CD68: Cluster of differentiation 68 TNF-: Tumor necrosis factor-alpha IL-6: Interleukin-6 IL-10: Interleukin-10 MDA: Malondialdehyde SOD: Superoxide dismutase GPX: Glutathione peroxidase ZO-1: Zonula occludens-1 PCA: Principal component analysis DEGs: Differentially expressed genes GO: Gene ontology MAPK: Mitogen-activated protein kinase Rap1: Ras-associated protein 1 References Colorectal Surgery Group, Colorectal BoSCMA, Surgeon Committee SBCMDA

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Glutathione is a powerful antioxidant that plays a crucial role in enhancing immunity and removing harmful free radicals from the body