However, one potential downside of taking glutathione in the morning is that it can cause mild nausea or stomach upset in some people, particularly if taken on an empty stomach
Such high micromolar GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77
Our l-glutathione levels can decline for many reasons, but the main one is ageing
Cosmetic safety data from extended-use studies supports continuous application at the concentrations listed above
doi: 10.1016/j.freeradbiomed.2016.02.028 13
A related drug from the same mechanism, fosgonimeton, failed its Phase 2/3 Alzheimers trial in 2024