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To detect potential sources of heterogeneity, subgroup analyses were performed according to the predefined variables, including duration of the intervention, NAC dosage, study location and the type of control

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Shameli carried out the acquisition of data, analysis and interpretation of data collected and involved in drafting of manuscript, revision of draft for important intellectual content and give final approval of the version to be published

For example, the combination of the cancer drug Dasatinib and the natural compound Quercetin was shown to induce apoptosis in senescent cells in a variety of contexts in vitro and in vivo 1,4