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In studies of people with type 2 diabetes, side effects were the number one reason for stopping treatment, which can feel discouraging if you are just starting out

A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2

Richter G, Feddersen O, Wagner U, Barth P, Goke R, G B

100 Short-acting GLP-1RAs mimicking physiological processes may provide a gentler and more personalized treatment strategy

This is why GLP-1 is valuable when treating type 2 diabetes

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