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The FDA might require post-approval studies or risk management plans

Patients should be aware of the signs of hyperkalemia (and hypokalemia) and seek immediate medical attention if they experience any of them

Bone marrow biopsy is sometimes done to evaluate for aplastic anemia, leukemia, lymphoma, or metastatic cancer to the bone marrow

Merck has built a patent estate around pembrolizumab that includes composition-of-matter patents on the antibody structure, method-of-use patents covering its approved indications (pembrolizumab has over 40 FDA-approved indications and indication-specific dosing regimens), and formulation patents on its IV formulation and concentration