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Pendulum is a team made up of experts in microbiology, biochemistry, medicine and nutrition, including Colleen Cutcliffe Ph.D

A recent study found that the triple agonist retatrutide for GLP-1R, GIPR and GCGR substantially induced weight loss in obese adults, demonstrating the clinical potential of this triple agonist for obesity treatment

If you don't lose 5% of your weight after 12 weeks of taking Contrave, your doctor may tell you to stop taking it because it's unlikely to work for you, the FDA says

It also has the highest thermic effect of food , requiring more energy for digestion and metabolism than other macronutrients

Think of eating on retatrutide as fueling your body, not feeding your appetite

This slow increase allows your body to adjust to the medication while minimizing common side effects like nausea