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A study of the subcellular localization of GPx1 variants to appreciate the molecular consequences associated with diseases demonstrated that the primary sequence of GPx1 affects subcellular localization and that the sequence and cell location can be important to understand the impact of GPx1 on human diseases, including cancer [24]

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Chemokines such as RANTES and MCP-1 recruit more immune cells, particularly macrophages, to the sites of inflammation, potentially perpetuating the cycle [68]

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260,262 Ferroptosis in hyperlipidemia Lower GPX4 activity and the massive lipid peroxides accumulation are the main reasons of ferroptosis