The plethora of structural information, together with the increasing power of computational facilities and refinement of binding prediction tools (110, 112, 119), open the possibility to design peptides/peptidomimetics able to target the translation complexes, with the aim to decrease protein synthesis of specific neuronal mRNAs and rescuing a healthy phenotype in individuals affected by FXS
The phase 1b, 16-week, multiple-dose ascending trial (NCT05613387) showed a mean body weight reduction of 4.8%, 8.6% and 8.3% at OW doses of up to 2.4 mg, 4.8 mg and 9.0 mg, respectively [116]
PubMed Chantachaeng W, Chularojanamontri L, Kulthanan K, Jongarearnprasert K, Dhana N
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Lycopene 2500 mcg
Research has found that asparagus may help reduce cholesterol levels by improving the binding capacity of bile acids during digestion