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Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants

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Combined treatment strategy: When used in combination with lipopolysis components such as caffeine and capsaicin, it can further enhance fat breakdown and thermogenic effects by activating adenylate cyclase (AC) and promoting the expression of uncoupled protein 1 (UCP1)

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In: Comprehensive toxicology