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The tryptophan-kynurenine pathway functions as a stress-activated metabolic system that diverts tryptophan from serotonin synthesis toward kynurenic acid production, which acts as a glutamate receptor antagonist and may contribute to anxiety pathophysiology through altered glutamatergic neurotransmission (Butler et al., 2022)

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It is possible that, in the future, the FDA will approve very small GLP-1 doses to treat conditions for which these drugs are not currently approved, such as type 1 diabetes

10.2337/diacare.29.01.06.dc05-0776

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In clinical trials, patients using Mounjaro have experienced a 5% to 15% reduction in body weight over 6 months, although individual results can vary