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Metabolite 2-methylthiophosphate is an endogenous inhibitor of PRMT5

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This typically includes thyroid ultrasound examination to assess for nodules or structural abnormalities, and potentially fine-needle aspiration biopsy of suspicious lesions

Protein quantification and statistical analysis were performed using the Proteomics Toolset for Integrative Data Analysis (Protigy, version 1.0.7, Broad Institute

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This specific structure is what makes the molecule so stable and allows it to perform its protective duties without being easily broken down by other cellular enzymes